Indie Bound is this great website whose goal is build support for independent community bookstores. Indie Bound's mission is stated as a goal "to band together with like-minded folks across the country to celebrate our independent natures, our free-thinking retailers and our unique communities".
It is a great place to find interesting, new books that you might not find at Barnes and Noble and Borders. Every week, Indie Bound lists the hottest indie bestsellers.
Check out Indie Bound at www.indiebound.org.
These are my favorite independent bookstores in South Florida:
Books and Books (Coral Gables, South Beach, Bal Harbor - www.booksandbooks.com)
The Bookstore in the Grove (Coconut Grove)
Well Read Used Books (Fort Lauderdale)